A- A+

Calcium Orotate Review

Calcium orotate is mysterious. There is surprisingly little information calcium-orotate | Review Articleabout this supplement among popular medical sources and in research.  Like coral calcium supplements, it is commonly marketed as a panacea nutrient for bone loss, weight loss, and 22 diseases and conditions.

According to Livestrong.com:

“Two molecules of orotic acid combine to form a single molecule of calcium orotate, in which a calcium atom takes the place of two hydrogen atoms (one H atom from each of the orotic acids). Calcium orotate is found in almost all living organisms in small quantities.

German physician Dr. Hans Nieper first used calcium orotate as a supplement for calcium intake.  Nieper suggested that orotates are mush [sic] more efficient at acting as the bioavailability enhancers for various minerals (e.g., calcium) instead of using the other forms of bioavailability enhancers like chlorides, carbonates, sulfates and many other anions.”

Calcium orotate has been described as molecular medicine.  According to the Linus Pauling Institute:

“The word "orthomolecular" was introduced by Linus Pauling in "Orthomolecular Psychiatry", his seminal 1968 article published in the journal Science... He later broadened this definition to include orthomolecular medicine, which he defined as "the preservation of good health and the treatment of disease by varying the concentrations in the human body of substances that are normally present in the body". He sometimes appended "and are required for health" to this definition and noted, "the adjective orthomolecular is used to express the idea of the right molecules in the right concentration" (emphasis added). The treatment of diabetes by the injection of insulin and the prevention of goiter with iodine are other instances of orthomolecular medicine.

Orthomolecular medicine is not "alternative"; rather, it should be considered as an adjunct to appropriate conventional medicine. Pauling became especially fascinated with vitamin C in the mid-1960s and quickly recognized that the intake of this vitamin and, consequently, its concentration in the body, significantly influences health and disease.

Research in orthomolecular nutrition and medicine forms the basis of the mission of the Linus Pauling Institute. Our faculty are particularly interested in determining the body's optimal concentration of various substances from food, including vitamins, micronutrients, and phytochemicals, that leads to the best of health and affords the greatest protection against disease."

Absent Research for Calcium Orotate
There is no clinical or animal research cited from companies that sell this type of calcium, other than to discuss the benefit to bone of generic calcium intake.  The product is touted as most effective form of calcium supplement, claiming that research shows that orotates penetrate cell membranes, enabling the effective delivery of the calcium ion to the inner-most layers of the cellular mitochondria and nucleus. No references to any study are provided, nor are there any published studies found on MEDLINE, a leading source of published medical research. It appears to be strictly theoretical. The product lacks all evidence of absorption, bone density increase or fracture risk reduction.

calcium-orotate | ArticleLinus Pauling was certainly a leading pioneer and chemist.. It appears that he never worked directly with calcium orotate. Others applied Pauling’s concepts  to calcium supplementation. This calcium form appears to novel, but untested.  As with any unproven compound, especially one touted as a panacea for many conditions and diseases based solely on theoretical evidence – buyer beware with calcium orotate.