A- A+

Calcium D Glucarate and Bone Loss

Calcium D glucarate is generally not regarded as a supplement for bone loss.  calcium_d-glucarate-and-bone-loss | ArticleSome people believe it offers protective medicinal properties, including detoxification and more serious indications.

According to Memorial Sloan Kettering‘s website:

“Calcium glucarate is the salt and the commercial form of glucaric acid. Glucaric acid occurs naturally in a variety of foods, including oranges, broccoli, and potatoes. The glucarate component, not the calcium, is thought to account for its activity. Following administration, glucarate is converted to d-glucaro-1,4-lactone, which inhibits beta-glucuronidase.

D-glucarate salts are absorbed in the stomach as D-glucaric acid or metabolized by gut bacteria. D-glucaric acid is converted to D-glucaro-1,4-lactone and D-glucaro-6,3-lactone. D-glucaro-1,4-lactone is extensively distributed throughout the body, present in all tissues and body fluids (4). Excretion is primarily in the urine with minimal amounts present in feces.”

According to WebMD.com:

"The appropriate dose of calcium D glucarate depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for calcium D-glucarate. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

Alcohol interacts with calcium D glucarate.

The body breaks down calcium D-glucarate to get rid of it. Alcohol might increase how fast the body gets rid of calcium D-glucarate. By increasing how fast the body gets rid of calcium D-glucarate, alcohol might decrease the effectiveness of calcium D-glucarate. Medications changed by the liver (Glucuronidated drugs) interacts with calcium d glucarate  The body breaks down some medications to get rid of them. The liver helps break down these medications. Calcium D glucarate might increase how quickly some medications are broken down by the liver. Taking calcium D glucarate along with medications changed by the liver might decrease the effectiveness of these medications.

Some of these medications changed by the liver include acetaminophen (Tylenol, others), atorvastatin (Lipitor), diazepam (Valium), digoxin, entacapone (Comtan), estrogen, irinotecan (Camptosar), lamotrigine (Lamictal), lorazepam (Ativan), lovastatin (Mevacor), meprobamate, morphine, oxazepam (Serax), and others.

Kanamycin interacts with calcium D glucarate.  Kanamycin is an antibiotic. The body breaks down kanamycin to get rid of it. Calcium D glucarate might increase how quickly the body gets rid of kanamycin. Taking calcium D glucarate along with kanamycin might decrease the effectiveness of kanamycin."

We found no published research studies for calcium D glucarate for bone health.  While the supplement does contain calcium, that mineral may not be available at sufficient levels or be in a highly absorbable form.  A more prudent action for building bone density may be taking a calcium supplement, such as AdvaCAL, with a clinical track record of increasing bone density. Moreover, people who could benefit from calcium D glucarate also may be at risk for low bone density. In those cases, one should consider taking AdvaCAL as a bone building complement to calcium D glucarate.