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Calcium glycerophosphate Review

calcium-glycerophosphate | Article

Calcium glycerophosphate is a relatively new mineral complex primarily used to neutralize acidic foods when consumed and to protect teeth.  It appears to not be extensively researched, if at all, for bone loss.  Much science of this dietary supplement has been focused on cavity prevention. 

According to Wisegeek.com, calcium glycerophosphate contains equal amounts of calcium and phosphorous. It appears to be an analog of calcium phosphate.  Like calcium hydroxyapatite, its main components are naturally found in bone:

“As a supplement, calcium glycerophosphate is available as Prelief®. Studies have found that calcium glycerophosphate can significantly reduce the urge to urinate, as well as minimize discomfort experienced after consuming highly acidic foods and beverages….by 60 percent and coffee by 95 percent.  However, most of the studies on calcium glycerophosphate conducted so far have been performed by the manufacturer and not an independent third party. It should also be noted that long-term calcium glycerophosphate supplementation may still carry the potential to decrease normal levels of stomach hydrochloric acid. Therefore, the manufacturer of Prelief® recommends limiting supplementation to only those times when one expects to eat acidic foods.”

Benefits for the Mouth
Research on calcium glycerophosphate suggests that a strong benefit may be its ability to inhibit plaque formation and tooth decay (“caries”) in the mouth. In an article entitled   Calcium glycerophosphate and caries: a review of the literature, (Int Dent J. 2004;54(5 Suppl 1):310-4), Lynch wrote:

“There is credible evidence that calcium glycerophosphate has the potential to reduce the progression of caries via all of these mechanisms if it is applied frequently and at a sufficiently high concentration. Reduction of plaque mass has also been proposed as a cariostatic mechanism but this seems less likely. Animal studies have shown that the calcium glycerophosphate/sodium monofluorophosphate system can have a greater anti-caries effect than sodium monofluorophosphate alone and this was subsequently confirmed in a caries clinical trial. We conclude that elevation of calcium levels in plaque is the most likely explanation and that any means of enhancing this effect has significant promise as a means to further increase in anti-caries potential of the [ this compound]/sodium monofluorophosphate system compared to sodium monofluorophosphate alone."

There are dozens of types of calciums available today; most sold as supplements or food additives. calcium-glycerophosphate | ArticleMany are designed to stabilize or enhance bone health. AdvaCAL calcium supplement is one brand with published research showing that it can actually increase bone density in postmenopausal women and men as well as in elderly women. That said -- AdvaCAL has no published research on tooth decay, although the calcium oxide and calcium hydroxide in AdvaCAL is alkaline and may help neutralize acidic foods. Without research, any potential benefit claim for tooth decay from AdvaCAL would be fully speculative. The same can probably be said for significant bone density improvement with a product containing calcium glycerophosphate.