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Calcium Hydroxide and Calcium Oxide Efficacy and Safety

Calcium hydroxide is the primary form of calcium found in AdvaCAL supplements. calcium-oxide-and-hydroxide | Article The other is calcium oxide.  The two calcium forms in AdvaCAL are proprietary. They are not available in competitive calcium supplements. 

Sometimes called slaked lime, calcium hydroxide is typically produced  by blending calcium oxide (also referred to as quicklime) with water. It can also be precipitated by mixing aqueous calcium chloride with aqueous sodium hydroxide. A suspension of fine calcium hydroxide particles in water is referred to as milk of lime. Calcium oxide and hydroxide have a highly alkaline pH, more so than other calcium forms.

Production of Calcium Hydroxide in Japan
The calcium hydroxide in AdvaCAL is produced differently in Japan. Calcium hydroxide in AdvaCAL is formed through in vaccu heating of oyster shell, at 800 degrees centigrade. Such heating burns carbon dixode from the oyster shell, creating  an ash of calcium oxide.  When exposed to ambient moisture in the air, some of the calcium oxide converts to calcium hydroxide.  

Like other forms of calcium, calcium hydroxide has industrial, food or medical applications. It is used in steel production, water treatment, mortar production, dentistry, glass manufacturing and to pickle foods. It is more commonly used in farming to alkalize acid crop soil.  Also, calcium naturally fosters healthy plant growth.

calcium-oxide-and-hydroxide | Article
Both calcium oxide and calcium hydroxide are listed  by the Food & Drug Administration (FDA) as GRAS or Generally Regarded As Safe.  Because the FDA does not formally approve most foods, supplements or food ingredients, GRAS is the  standard used by most companies to determine the safety of foods and dietary supplements in the United States.  That said, high levels of exposure of many GRAS ingredients, including calcium, can cause a reaction.  For example, calcium hydroxide,  calcium oxide, and calcium carbonate all feature similar material safety precautions, although calcium carbonate is less alkaline.  These precautions include:


  • Inhalation: Remove to fresh air.
  • Ingestion: Do not induce vomiting.  Give large quantities of water.
  • Skin contact: Wipe off excess material from skin then immediately flush skin with plenty of water for at least 15 minutes.
  • Eye Contact: Immediately flush eyes with gentle but large stream of water for at least 15 minutes, lifting lower and upper eyelids occasionally.

These precautionary measures generally reflect significant exposure to a calcium powder, not the encapsulated or tableted products sold as dietary supplements.

To date, there have been 20 medical studies published on the calcium oxide and hydroxide in AdvaCAL. There have been no toxicity or safety issues reported in those studies any different than found in people taking a placebo or calcium carbonate.  Moreover, LaneLabs has not received any serious complaints on AdvaCAL, since it was introduced in 1999.  AdvaCAL has helped thousands in supporting/ increasing bone density. Critical to its efficacy and success is its unique calcium oxide and calcium hydroxide.