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Supplement Facts and Directions


AdvaCAL is Gluten Free, Lactose Free


Direction For use:
Take 3 capsules in the morning and 3 capsules at bedtime, preferably with food.

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AAACa Calcium™ (Active Absorbable Algal Calcium)

AAACa Calcium is an ionic calcium. It starts out as oyster shell that is smelted at a temperature of 800° C. This extreme heat changes the chemical structure of oyster shell from calcium carbonate to calcium oxide and calcium hydroxide. The superheating process removes nearly all of the heavy metals, such as lead, found in oyster shell.

AAACa is unique, offering superior absorption and parathyroid hormone (“PTH”) modulation. Calcium absorption and PTH modulation are keys to active, natural bone building. AAACa’s enhanced activity is attributed to two major product characteristics: 1. the calcium is ionic and 2. its complexation with an algae, rich in amino acids.. Because it is ionic and highly soluble, AAACa calcium is well absorbed irrespective of acidity of the stomach which is in sharp contrast to other calcium types. The amino acids in AAACa act as a natural carrier of calcium from the intestine to the blood. AAACa calcium’s enhanced absorption and PTH modulation have demonstrated significant bone benefits in research.*




According to the Association of Women for the Advancement of Research and Education “Studies have shown that 3 milligrams (mg) of boron daily reduces urinary excretion of calcium and magnesium, especially when dietary magnesium is low. Boron supplementation elevates the serum concentrations of 17 beta estradiol and testosterone, again when dietary magnesium is low. The findings suggest that supplementation of a low-boron diet with an amount of boron commonly found in diets high in fruits and vegetables induces changes in postmenopausal women consistent with the prevention of calcium loss and bone demineralization.*  Cabbage ranks highest in boron content among leafy vegetables, with 145 parts per million (ppm) on a dry-weight basis. Dandelion shoots run a close second with 125 ppm. Dandelion also has more than 20,000 ppm of calcium, meaning that just under 7 tablespoons of dried dandelion shoots could provide more than 1 mg of boron and 200 mg of calcium.” The forms of boron in AdvaCAL Ultra 1000 is boron citrate, aspartate and glycinate

Association of Women for the Advancement of Research and Education " Improving & Maintaining Bone Health” 2001. http://www.project-aware.org/Health/Osteo/osteo-bonehealth.shtml#calcsupp



According to the U.S. National Institutes of Health (NIH) “Copper helps certain enzymes and local regulators function properly so that we can form the optimal bone matrix or structure for bone strength.*  Calcium supplementation may result in lower levels of copper. Good sources of copper include organ meats, seafood, nuts, seeds, wheat bran, cereals, whole grain products, cocoa products. The form of copper in AdvaCAL Ultra 1000 and AdvaCAL INTENSIVE is copper citrate.

NIH : National Resource Center “Other Nutrients and Bone Health At a Glance” December 2004



HAI (Heated Algal Ingredient)

HAI is an amino acid complex from super-heated hijiki seaweed. Tiny amounts of HAI have been scientifically shown to further elevate calcium oxide & calcium hydroxide absorption. Calcium oxide/calcium hydroxide + HAI provides superior calcium absorption and PTH modulation. This combination has demonstrated consistent improvements in bone mineral density in clinical research.* These two ingredients are only available in AdvaCAL.

Fujita T, Fujii Y, Goto B, Miyauchi A,Takagi Y. “A Three Year Comparative trial : Effect of combined alfacalcidol and elcatonin” J Bone Miner Metab (1997) 15:223-226
Fujita T, “Calcium Bioavailability from Heated Oyster Shell-Seaweed calcium (Active Absorbable Algal calcium) as Assessed by Urinary Calcium, Excretion” J. Bone Miner Metab (1996) 14:31-34
Fujita T, Ohgitani S. , Fujii Y. “Overnight Suppression of Parathyroid Hormone and Bone Resorption Markers by Active Absorbable Algal Calcium. A Double-Blind Crossover Study” Calcif Tissue Int (1997) 60, 506-512
Fujita T, Fujii Y, Goto B , Miyauchi A, Takagi Y, Kobayashi S, Komoshita K, et al Increase of Intestinal Calcium Absorption and Bone Mineral Density by Heated Algal-Ingredient (HAI) in Rats J Bone Miner Metab (2000) 18:165-169
Fujita T, Ohue M, Fujii Y, Miyauchi A, Takagi T “Reappraisal of Katsuragi Calcium Study, A Prospective, Double-Blind, Placebo-Controlled Study on the Effect of Active Absorbable Algal Calcium (AAACa) on Vertebral Deformity and Fracture” J. Bone Miner Metab (2004) 22:32-38

More AAACa & HAI Studies



According to the U.S. National Institutes of Health (NIH) “Magnesium is the fourth most abundant mineral in the body and is essential to good health. Approximately 50% of total body magnesium is found in bone. The other half is found predominantly inside cells of body tissues and organs. Only 1% of magnesium is found in blood, but the body works very hard to keep blood levels of magnesium constant…. It helps maintain normal muscle and nerve function, keeps heart rhythm steady, supports a healthy immune system, and keeps bones strong.*
Green vegetables such as spinach are good sources of magnesium because the center of the chlorophyll molecule (which gives green vegetables their color) contains magnesium. Some legumes (beans and peas), nuts and seeds, and whole, unrefined grains are also good sources of magnesium.” According to the U.S. Institutes of Medicine “Two studies are available on the effect of magnesium supplementation on [bone loss].  In women with documented [bone loss], supplementation with 750 mg (31.3 mmol) of magnesium for the first 6 months followed by 250 mg (10.4 mmol) supplementation from the seventh to twenty-fourth month increased radial BMD after 12 months, but no further change was seen in BMD by the end of the second year (Stendig-Lindberg et al., 1993). Supplementation with 500 mg (20.8 mmol) of magnesium and 600 mg (15 mmol) of calcium in postmenopausal women who were receiving estrogen replacement therapy and daily multivitamin and mineral tablets resulted in increased calcaneous BMD in less than a year when compared with the postmenopausal women who received sex steroid therapy alone (Abraham and Grewal, 1990). These observations suggest that dietary magnesium may be related to [bone loss] and indicate a need for further investigation of the role of magnesium in bone metabolism (Sojka and Weaver, 1995).”  A clinical study published in 1999 suggests that the bone benefit of magnesium may result from its alkalinity (or higher pH). Magnesium intake benefits were no different than those consuming potassium or fruits and vegetables, all of which are alkaline. Since the pH of AdvaCAL calcium is highly alkaline, (more so than other calcium forms), the benefits of magnesium intake for bone health may be already present in AdvaCAL.*  The magnesium forms in AdvaCAL Ultra 1000 are magnesium oxide and magnesium citrate.

http://dietary-supplements.info.nih.gov/factsheets/magnesium.asp Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride (1997) Institute of Medicine (IOM) page 201.
Tucker K, Hannan T, Chen H, et al “Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Am J Clin Nutr 1999: 69 727-36



According to the U.S. National Institutes of Health (NIH) “Manganese helps certain enzymes and local regulators function properly so that we can form the optimal bone matrix or structure for bone strength.*  Good sources of manganese include nuts, legumes, tea, whole grain and drinking water. The form of manganese in AdvaCAL Ultra 1000 and AdvaCAL INTENSIVE is manganese sulfate.

NIH : National Resource Center “Other Nutrients and Bone Health At a Glance” December 2004



As noted in a recent published scientific article  "Accumulating evidence over the last 30 years strongly suggest that dietary silicon is beneficial to bone and connective tissue health and we recently reported strong positive associations between dietary Si intake and bone mineral density in US and UK cohorts. The exact biological role(s) of silicon in bone health is still not clear, although a number of possible mechanisms have been suggested, including the synthesis of collagen and/or its stabilization, and matrix mineralization. This review gives an overview of this naturally occurring dietary element, its metabolism and the evidence of its potential role in bone health."*

Reference:  R. Jugdaohsingh  J. Nut. Health Aging (2007) : 119(2) 99-110.


Vitamin C

A 2010 animal study, and others, have  confirmed earlier findings suggesting that Vitamin C deficiency contributes to bone loss. Researchers have speculated on the mode of action of this nutrient with bone formation, which may or may not have been confirmed in experimental studies.   However, it appears that the lack of antioxidants, such as Vitamin C, in the diet is correlated with higher bone loss.*

The Vitamin C in AdvaCAL Ultra 1000 is ascorbic acid.

Reference:  Medline Plus 2012


Vitamin D3

According to the U.S. National Institutes of Health (NIH)
“Vitamin D is a fat-soluble vitamin that is naturally present in very few foods, added to others, and available as a dietary supplement. It is also produced endogenously when ultraviolet rays from sunlight strike the skin and trigger vitamin D synthesis. Vitamin D obtained from sun exposure, food, and supplements is biologically inert and must undergo two hydroxylations in the body for activation. The first occurs in the liver and converts vitamin D to 25-hydroxyvitamin D [25(OH)D], also known as calcidiol. The second occurs primarily in the kidney and forms the physiologically active 1,25-dihydroxyvitamin D [1,25(OH)2D], also known as calcitriol.

Vitamin D is essential for promoting calcium absorption in the gut and maintaining adequate serum calcium and phosphate concentrations to enable normal mineralization of bone and prevent hypocalcemic tetany. It is also needed for bone growth and bone remodeling by osteoblasts and osteoclasts. Without sufficient vitamin D, bones can become thin, brittle, or misshapen.  Together with calcium, vitamin D also helps protect older adults from [bone loss].” The NIH’s Food and Nutritional Board is reviewing the currently recommended intake for vitamin D (400 IU per day in adults). Substantial new research has been published to justify a reevaluation of adequate vitamin D intakes for healthy populations. According to leading Vitamin D expert, Michael Holick, PhD, MD, “ a 1000 IU of vitamin D may help maintain BMD [bone mineral density] in hip and spine and can increase BMD in hip and spine for both men and women who are vitamin D deficient.”*  AdvaCAL contains the natural form of Vitamin D, D3 (Cholecalciferol).

Letter from Michael Holick to Andrew Lane, LaneLabs, December 1, 2008.


Vitamin K2

According to the National Institutes of Health (NIH) “The name "vitamin K" refers to a group of chemically similar fat-soluble compounds called naphthoquinones. Vitamin K1 (phytonadione) is the natural form of vitamin K, which is found in plants and provides the primary source of vitamin K to humans through dietary consumption. Vitamin K2 compounds (menaquinones) are made by bacteria in the human gut and provide a smaller amount of the human vitamin K requirement. “Vitamin K appears to prevent bone resorption and adequate dietary intake is likely necessary to prevent excess bone loss. Elderly or institutionalized patients may be at particular risk and adequate intake of vitamin K-rich foods should be maintained. Unless patients have demonstrated vitamin K deficiency, there is no evidence that additional vitamin K supplementation is helpful. Some studies show that vitamin K supplements may increase bone mineral density and bone strength, while others show that vitamin K has no effect on bone turnover.*  Furthermore, vitamin D and calcium supplementation may enhance the beneficial effects of vitamin K. Further research is needed to confirm these results.” Some researchers believe Vitamin K2 is more beneficial to bone than vitamin K1, but there is no consensus in the scientific community.

National Institutes of Health, Medline Plus August 2009. http://www.nlm.nih.gov/medlineplus/druginfo/natural/patient-vitamink.html
Plaza SM, Lamson DW. Vitamin K2 in bone metabolism, Altern Med Rev. 2005 Mar;10(1):24-35.


Zinc-Copper-Manganese Blend

According the Journal of Nutrition Healthy postmenopausal women were divided into several groups for a clinical study. Of particular interest were two groups: one took 1000 mg of calcium citrate malate; the other took 1000mg of calcium citrate malate and a blend of zinc, copper and manganese. After two years, average spinal bone density of the calcium citrate malate group was no different than those taking no calcium [placebo group]. The group taking calcium plus the zinc-copper-manganese blend, however, did show a statistical improvement to the placebo group. The bone density improvement to placebo was +5%.*  A daily serving of AdvaCAL INTENSIVE contains the same amount of the zinc-copper-manganese blend that was used in the clinical study.

Strause L, Saltman P, Smith K, Bracker M, Andon M “Spinal Bone Loss in Postmenopausal Women Supplemented with Calcium and Trace Minerals. J Nutr. 1994 Jul; 124(7): 1060-4.



According to the U.S. National Institutes of Health (NIH) “Zinc is an essential mineral that is naturally present in some foods, added to others, and available as a dietary supplement. Zinc is also found in many cold lozenges and some over-the-counter drugs sold as cold remedies.”

“Zinc is involved in numerous aspects of cellular metabolism. It is required for the catalytic activity of approximately 100 enzymes and it plays a role in immune function protein synthesis, wound healing, DNA synthesis and cell division…A daily intake of zinc is required to maintain a steady state because the body has no specialized zinc storage system.” A wide variety of foods contain zinc. Oysters contain more zinc per serving than any other food, but red meat and poultry provide the majority of zinc in the American diet. Other good food sources include beans, nuts, certain types of seafood (such as crab and lobster), whole grains, fortified breakfast cereals, and dairy products.” According to the Journal of Trace Elements in Experimental Medicine “Bone growth retardation is a common finding in various conditions associated with zinc deficiency, suggesting a physiological role of zinc in the growth and mineralization of bone tissue. Bone zinc content is decreased by development with aging, skeletal unloading, and postmenopausal conditions. Zinc deficiency may play a pathophysiological role in the deterioration of bone metabolism...Zinc inhibits osteoclastic bone resorption by inhibiting osteoclast-like cell formation from marrow cells. Zinc may act on the process of bone-resorbing factors-induced protein kinase C activation, which is involved in Ca2+ signaling in osteoclastic cells. Zinc plays a role in the preservation of bone mass.”*

The form of zinc in AdvaCAL Ultra 1000 and AdvaCAL INTENSIVE is monoethionate, which is a chelated zinc for proper absorption.*  "Chelated" means connected with another molecule; in this case the zinc salt is bonded to the amino acid monomethionine.

http://ods.od.nih.gov/FactSheets/Zinc.asp Yamaguchi, M. “Role of zinc in bone formation and bone resorption” J. Trace Elem. Exp. Med. 11:119-135, 1998


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